A Novel Giardia lamblia Nitroreductase, GlNR1, Interacts with Nitazoxanide and Other Thiazolides

Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2).

OBJECTIVES The protozoan parasite Giardia lamblia causes giardiasis, a persistent diarrhoea. Nitro drugs such as the nitroimidazole metronidazole and the nitrothiazolide nitazoxanide are used for the treatment of giardiasis. Nitroreductases may play a role in activating these drugs. G. lamblia contains two nitroreductases, GlNR1 and GlNR2. The aim of this work was to elucidate the role of GlNR2...

Giardia Lamblia.

Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole.

OBJECTIVES The characterization of Giardia lamblia WB C6 strains resistant to metronidazole and to the nitro-thiazole nitazoxanide [2-acetolyloxy-N-(5-nitro 2-thiazolyl) benzamide] as the parent compound of thiazolides, a novel class of anti-infective drugs with a broad spectrum of activities against a wide variety of helminths, protozoa and enteric bacteria. METHODS Issuing from G. lamblia W...

Giardia lamblia and Giardiasis

Introduction Ask the average outdoors person about Giardia lamblia, and they have certainly heard about it. Almost always, however, they are considerably misinformed about both the organism’s significance in wilderness water and the seriousness of the disease, giardiasis, if contracted. The amount of information easily found on the subject is voluminous. Unfortunately, almost all of it is flawe...

Identification of a Novel Microtubule-Binding Protein in Giardia lamblia

Giardia lamblia is a protozoan that causes diarrheal diseases in humans. Cytoskeletal structures of Giardia trophozoites must be finely reorganized during cell division. To identify Giardia proteins which interact with microtubules (MTs), Giardia lysates were incubated with in vitro-polymerized MTs and then precipitated by ultracentifugation. A hypothetical protein (GL50803_8405) was identified...